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SFB 1039

SIGNALLING BY FATTY ACID DERIVATIVES AND
SPHINGOLIPIDS IN HEALTH AND DISEASE

A02 - 5-Lipoxygenase und ihre Isoformen als Regulatoren der leukozytären Immunantwort

5-Lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid to leukotrienes (LT) und 5-hydroxyeicosatetraenoic acid (5-HETE). The 5-LO pathway is involved in adaptive humoral immune responses. At present, our knowledge about the regulation of 5-LO in B-lymphocytes is very limited. Within the applied project we want to study the regulation of the cellular 5-LO activity in B-lymphocytes with a special emphasis on two recently discovered 5-LO protein isoforms and we will investigate their physiologic function in immune reactions.

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Principal Investigator

Prof. Dr. Dieter Steinhilber
Institute of Pharmaceutical Chemistry
Goethe-University Frankfurt
Max-von-Laue-Str. 9
60438 Frankfurt am Main