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SFB 1039

SIGNALLING BY FATTY ACID DERIVATIVES AND
SPHINGOLIPIDS IN HEALTH AND DISEASE

A08 - Lipid-mediated interactions between peripheral neurons, thrombocytes and macrophages during inflammation and pain

Inflammatory pain is in part based on the sensitization of peripheral sensory neurons by lipids released from immune cells. We showed previously that platelets, which are associated with macrophages, can enter the inflamed tissue in several inflammation models. There, they suppress through the thromboxane receptor (TP) antiinflammatory phenotypes in macrophages and induce through TP the synthesis of proinflammatory mediators. Now we will investigate the most abundant lipids in platelets (thromboxane, 12S-HETE, 12-HHT), for their role in the activation of peripheral sensory neurons as well as the role of the subsequently induced neurotransmitter release for immune cell recruitment and macrophage polarization.

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Principal Investigator

Prof. Dr. Klaus Scholich
Institute of Clinical Pharmacology
Faculty of Medicine

Goethe-University Frankfurt
Theodor Stern Kai 7
60590 Frankfurt am Main

Prof. Dr. Dr. Gerd Geisslinger
Institute of Clinical Pharmacology
Faculty of Medicine

Goethe-University Frankfurt
Theodor Stern Kai 7
60590 Frankfurt am Main