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SFB 1039

SIGNALLING BY FATTY ACID DERIVATIVES AND
SPHINGOLIPIDS IN HEALTH AND DISEASE

A09 - Lipids synthesized via CYP epoxygenases in chronic inflammatory and neuropathic pain states

Previously, we could show a central role for oxidized linoleic acid metabolites and the G2A receptor (GPR132) in Chemotherapy-induced neuropathic pain (CIPN). CIPN is a mixed pain state, consisting of an inflammatory and a neuropathic component. We want to investigate the contribution of oxidized linoleic acid metabolites to these individual components separately during chronic inflammatory and neuropathic pain. Moreover, we want to clarify the role of the G2A receptor in these pain states in neurons and myeloid cells. Finally, we want to identify lipids, that are released from sensory neurons upon nociceptive activity and that may be involved in recruitment and migration of immune cells.

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Principal Investigator

Dr. Marco Sisignano
Institute of Clinical Pharmacology
Faculty of Medicine
Goethe-University Frankfurt
Theodor Stern Kai 7
60590 Frankfurt am Main