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SFB 1039

SIGNALLING BY FATTY ACID DERIVATIVES AND
SPHINGOLIPIDS IN HEALTH AND DISEASE

B02 - Sphingolipid- and matrix-mediated signalling pathways in chronic inflammation and fibrosis of the kidney

Sphingolipids and components of the extracellular matrix (ECM) play important roles in fibrotic diseases by regulating inflammation, proliferation and apoptosis. This project aims at investigating the impact of an interaction of sphingolipid and matrix signalling on the development of kidney fibrosis in vitro and in vivo using animal models of kidney fibrosis in mice with a pharmacological or genetic inhibition of sphingolipid or matrix signalling components. The long-term objective is to analyze whether the sphingolipid system or ECM components will serve as new targets for the treatment of chronic inflammatory and fibrotic processes.

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Principal Investigator

Prof. Dr. Josef M. Pfeilschifter
Institute of General Pharmacology and Toxicology
Faculty of Medicine
Goethe-University Frankfurt
Theodor Stern Kai 7
60590 Frankfurt am Main

Prof. Dr. Liliana Schaefer
Institute of General Pharmacology and Toxicology
Faculty of Medicine
Goethe-University Frankfurt am Main
Theodor Stern Kai 7
60590 Frankfurt am Main