B04 - Regulation and function of 15-lipoxygenase-2

Macrophages sense their microenvironment by changing their lipidome that, at least in part, is determined by lipoxygenases (ALOX). Following our work towards ALOX5 and ALOX15, pilot data now suggest a link between ALOX15B, the SREBP2 (sterol response-element binding protein 2) activity, and cholesterol metabolism. We aim at understanding molecular details of this interaction and explore functional consequences towards anti-viral and anti-bacterial macrophage responses. In the meantime, we generated global and conditional ALOX8 (murine analog of the human ALOX15B) knockout mice that will be tested using an established inflammatory (peritonitis) as well as breast tumor model.

Links:

• Institute of Biochemistry I