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SFB 1039

SIGNALLING BY FATTY ACID DERIVATIVES AND
SPHINGOLIPIDS IN HEALTH AND DISEASE

B04 - Role of sphingosine kinases and S1P receptors in tumor progression and macrophage polarization

We aim at understanding the role of SK1 and SK2 as well as of S1P receptors during tumor progression and the closely associated process of macrophage polarization. While performing experiments in SK1 vs. SK2 knockout mice, we make use of two tumor models, bone marrow transplantation experiments and a chemotherapy model. Furthermore, we analyze the impact of individual S1P receptors during macrophage reprogramming and tumor progression and determine the contribution of SK2 in modulating macrophage polarization programs. Besides sphingolipids we try to understand the contribution of lipoxins (LXA4) and resolvines (D1) in the tumor microenvironment.

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Principal Investigator

Prof. Dr. Bernhard Brüne
Institute of Biochemistry I
Faculty of Medicine
Goethe-University Frankfurt
Theodor Stern Kai 7
60590 Frankfurt am Main