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SFB 1039

SIGNALLING BY FATTY ACID DERIVATIVES AND
SPHINGOLIPIDS IN HEALTH AND DISEASE

B06 - Impact of tumor-associated lipidome alterations on inflammation

Alterations in the lipidome in tumor versus normal tissue lead to the production of lipid antigens, especially ether phosphatidylserine (ePS) species, for type II NKT cells, which consequently promote tumor development. In the current project, we ask for NKT cell-independent mechanisms of the anti-inflammatory and thereby tumor-promoting effect of ePS. Following the reverse argument, we analyze whether the application of ePS limits chronic inflammation via NKT-dependent or independent mechanisms. Finally we investigate the role of Lyso-Sphingomyelin as a protective lipid antigen in tumors and explore mechanisms of its decreased formation.

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Principal Investigator

PD Dr. Andreas Weigert
Institute of Biochemistry I
Faculty of Medicine
Goethe-University Frankfurt
Theodor Stern Kai 7
60590 Frankfurt am Main