Goethe Universität Logo DFG Logo LiFF Logo Max Planck Institut Logo

SFB 1039

SIGNALLING BY FATTY ACID DERIVATIVES AND
SPHINGOLIPIDS IN HEALTH AND DISEASE

B08 - Role of the sphingolipid signalling pathway and metabolism in the acute injury and regeneration of the neurovascular unit

The aim of our project is to spatio-temporally characterize the sphingolipid signalling pathway on a cellular and brain regional level in the acute phase and recovery after ischemic stroke and in septic encephalopathy. Our focus lies on the neurovascular unit as the primary scene of acute injury and repair processes. Applying primary cell culture models of the blood-brain barrier, animal models of stroke and septic encephalopathy and patient samples, we plan to explore the pathophysiological role of sphingolipid mediators in the course of stroke and septic encephalopathy and the potential of their receptors and metabolizing enzymes to serve as novel therapeutic targets for acute brain diseases and regeneration.

Links:

Principal Investigators

Prof. Dr. med. Waltraud Pfeilschifter
University Hospital Frankfurt
Department of Neurology
Center of Neurology and Neurosurgery
Theodor Stern Kai 7
60590 Frankfurt am Main

Dr. med. Robert Brunkhorst
University Hospital Frankfurt
Department of Neurology
Center of Neurology and Neurosurgery
Theodor Stern Kai 7
60590 Frankfurt am Main