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SFB 1039

SIGNALLING BY FATTY ACID DERIVATIVES AND
SPHINGOLIPIDS IN HEALTH AND DISEASE

A06 - Title Role of adipocyte, pancreatic and hepatic fatty acid epoxides and diols in the development of the metabolic syndrome

Cytochrome P450 (CYP) enzymes generate a spectrum of epoxides derived from polyunsaturated fatty acids (PUFA), that can be further metabolised by the soluble epoxide hydrolase (sEH). Deletion of the sEH, increases epoxide levels and protects against the development of the metabolic syndrome. sEH deletion also modulated the expression of a network of molecules all related to cholesterol packaging, transport and uptake in wild-type and sEH-/- littermates. This project now aims to identify the lipid mediator involved, focus on the role of the CYP/sEH axis in the pancreas and diabetes-induced ER stress and study the role of the sEH in adipocyte differentiation and the consequences of adipocyte-specific sEH deletion on insulin sensitivity.

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Principal Investigator

Prof. Ingrid Fleming, PhD
Institute for Vascular Signalling
Centre of Molecular Medicine
Faculty of Medicine
Goethe-University Frankfurt
Theodor-Stern-Kai 7
60590 Frankfurt am Main