A02 - 5-Lipoxygenase and its Isoforms as Regulators of Leukocyte Immune Functions
5-Lipoxygenase (5-LO) calalyzes the conversion of arachidonic acid into biologically active leukotrienes. We could identify three 5-LO splice variants which are expressed in lymphocytes and in monocytes from septic patients and which encode for short 5-LO protein isoforms. Data obtained in our group during the last years suggest that 5-LO has alternative functions than the formation of leukotrienes and that 5-LO is involved in the regulation of gene transcription by the modulation of the activity of distinct transcription factors such as p53 and NFkB. During the next funding period we will investigate the role of 5-LO and its isoforms as modulators of NFkB signal transduction.
Prof. Dr. Dieter Steinhilber
Institute of Pharmaceutical Chemistry
60438 Frankfurt am Main