A02 - 5-Lipoxygenase und ihre Isoformen als Regulatoren der leukozytären Immunantwort
5-Lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid to leukotrienes (LT) und 5-hydroxyeicosatetraenoic acid (5-HETE). The 5-LO pathway is involved in adaptive humoral immune responses. At present, our knowledge about the regulation of 5-LO in B-lymphocytes is very limited. Within the applied project we want to study the regulation of the cellular 5-LO activity in B-lymphocytes with a special emphasis on two recently discovered 5-LO protein isoforms and we will investigate their physiologic function in immune reactions.
Prof. Dr. Dieter Steinhilber
Institute of Pharmaceutical Chemistry
60438 Frankfurt am Main