A08 - Lipid-mediated interactions between peripheral neurons, thrombocytes and macrophages during inflammation and pain

Inflammatory pain is in part based on the sensitization of peripheral sensory neurons by lipids released from immune cells. We showed previously that platelets, which are associated with macrophages, can enter the inflamed tissue in several inflammation models. There, they suppress through the thromboxane receptor (TP) antiinflammatory phenotypes in macrophages and induce through TP the synthesis of proinflammatory mediators. Now we will investigate the most abundant lipids in platelets (thromboxane, 12S-HETE, 12-HHT), for their role in the activation of peripheral sensory neurons as well as the role of the subsequently induced neurotransmitter release for immune cell recruitment and macrophage polarization.

Links:

• Institute for Clinical Pharmacology