B05 - CerS in colon cancer: Influence on T-cells and tumor environment

Using human and mice primary T-cells, we investigate the role of ceramide synthases on T-cell signaling, development and activity. Furthermore, the impact of various ceramide synthases on the communication between T-cells and colon cancer cells are investigated. In vivo, we ascertain the influence of ceramide synthases in T-cells on the development of colitis and colitis associated carcinogenesis. At the end we want to bring together evidence, whether the expression of specific ceramide synthases in T-cells is a prognostic marker for T-cell activity under inflammatory condition or important for the anti-tumorigenic activity of T-cells.

Links:

• Institute of Clinical Pharmacology