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SFB 1039

SIGNALLING BY FATTY ACID DERIVATIVES AND
SPHINGOLIPIDS IN HEALTH AND DISEASE

B05 - Cell type specific action of CerS in the AOM/DSS induced cancer model

Six different ceramide synthases produce ceramides of specific chain length, which are important compounds of cell membranes and act as second messengers. In our preliminary work we found out that AOM/DSS induced colitis and carcinogenesis is affected in different CerS-knockout mice. In the next funding period we want to analyze by proteomanalysis the impact of ceramides with specific chain length on membrane proteins. We want to find out how these lipids influence the function and development of T-cells and the barrier function of colon epithelial cells. In blood and tissue of colitis patients ceramides will be determined as potential biomarker.

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Principal Investigator

Prof. Dr. Sabine Grösch
Institute of Clinical Pharmacologye
Faculty of Medicine
Goethe-University Frankfurt
Theodor Stern Kai 7
60590 Frankfurt am Main