B05 - The role of ceramide synthases in chronic inflammatory bowel disease as precancerous model of colon cancer
Within this project we investigate the influence of deregulated CerS expression levels, accompanied by deregulated ceramide levels, in immunocytes and colon epithelial cells. Their effect on the production of reactive oxygen-species and cytokines by immunocytes as well as the activation of various stress signalling cascades and the occurrence of DNA-damage in colon epithelial cells are analyzed. In vitro and in vivo the influence of sphingolipid-antigens of different chain length on NKT-cell differentiation is investigated. In different mouse models the expression of CerS in either colon epithelial cells or immunocytes are deregulated and the effect on the development of colitis and colon-carcinoma is investigated.
Prof. Dr. Sabine Grösch
Institute of Clinical Pharmacologye
Faculty of Medicine
Theodor Stern Kai 7
60590 Frankfurt am Main