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SFB 1039

SIGNALLING BY FATTY ACID DERIVATIVES AND
SPHINGOLIPIDS IN HEALTH AND DISEASE

A05 - Mitochondrial dynamics in macrophages in response to fatty acids

Mitochondrial metabolism is a known regulator of macrophage polarization. Our research proposal for the next funding period focuses on elucidating the mechanisms of fatty acid-induced mitochondrial fragmentation. We suggest that mitochondrial uncoupling and altered mitochondrial lipid composition are crucial for the fragmentation. Further we aim to clarify the role of mitochondrial fragmentation in inflammatory responses of macrophages in vitro and in mouse models of insulin resistance. Last, we investigate the influence of mitochondrial fragmentation on the mitophagy as well as the impact of AMP-activated protein kinase on the fragmentation.

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Principal Investigator

PD Dr. Dmitry Namgaladze
Institute of Biochemistry I
Faculty of Medicine
Goethe-University Frankfurt
Theodor-Stern-Kai 7
60590 Frankfurt am Main