A07 - Dual modulators of soluble epoxide hydrolase and peroxisome-proliferator activated receptor γ for treatment of stroke

Project A07 comprises development, in vitro characterization and in vivo evaluation of dual modulators of soluble epoxide hydrolase (sEH) and peroxisome-proliferator activated receptor γ (PPARγ) for organ protection mediated by synergistic accumulation of intracellular sphingosine-1-phosphate (S1P). Stereoselective multi-gram synthesis of active compounds will be established. In parallel, novel dual sEH/PPARγ modulators, which can penetrate the blood-brain barrier will be designed and synthesized. In vivo evaluation of most promising compounds in murine models of renal fibrosis, cardiac infarction, and stroke is planned in collaboration with other SFB members in order to establish a novel therapeutic option for treatment of these diseases.

Links:

• Institute of Pharmaceutical Chemistry