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SFB 1039

SIGNALLING BY FATTY ACID DERIVATIVES AND
SPHINGOLIPIDS IN HEALTH AND DISEASE

A03 - Endocannabinoid deficiency and Parkinson-associated pain

Parkinson-associated pain is one of the early non-motor manifestations of PD, difficult to treat, and often responding only to cannabis. It is associated with FAAH polymorphisms suggesting deregulations of endocannabinoids (eCBs), and indeed our studies revealed a remarkable eCB deficiency in PD-patients and PD-mice. We will proceed with this translational approach to address disease-state dependent eCB deregulations, functional consequences and molecular mechanisms. eCBs and other lipids shall be analyzed in parallel with quantitative sensory tests including nociception. In PD-mice we will therapeutically restore eCBs, observe the outcome and study the interrelationship of dopamine and eCBs. Finally, we will generate iPSC derived sensory neurons of PD patients for functional studies.

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Principal Investigator

Prof. Dr. Irmgard Tegeder
Institute of Clinical Pharmacology
University Hospital Frankfurt
Goethe-University Frankfurt
Theodor Stern Kai 7
60590 Frankfurt am Main