A03 - Endogenous cannabinoid-mediated pain inhibition and aging
This project will address the question whether impaired endocannabinoid-mediated endogenous pain inhibition enhances the risk for chronic pain in the elderly and whether chronic pain accelerates aging processes. We will analyze endocannabinoids, nociception, anxiety, neuronal and glial morphology and physiological parameters in a model of chronic neuropathic pain in senescence accelerated and cannabinoid-receptor deficient mice and use pharmacological and genetic manipulations to assess the therapeutic reversibility of endocannabinoidallostasis.
Prof. Dr. Irmgard Tegeder
Institute of Clinical Pharmacology
University Hospital Frankfurt
Theodor Stern Kai 7
60590 Frankfurt am Main