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SFB 1039

SIGNALLING BY FATTY ACID DERIVATIVES AND
SPHINGOLIPIDS IN HEALTH AND DISEASE

B04 - S1P-receptors and lipoxygenase products in macrophages during inflammation and in tumors

Macrophages coordinate initiation and resolution of inflammation, while during cancer immunoediting they often promote tumor progression. The macrophage phenotype is determined by e.g. sphingolipids and lipoxygenase products. Using the model of imiquimod-induced psoriasis we explore how macrophage S1P-receptors, especially S1P1, alters markers of inflammation and disease progression. We hypothesize that S1P-stimulated lymphangiogenesis promotes healing. Further experiments address the role of 5- and 15-lipoxygenases during macrophage polarization, their signal cross-talk with tumor cells, and other immune competent cells. This will elucidate the role of these lipoxygenases in the tumor stroma during tumor initiation and progression.

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Principal Investigator

Prof. Dr. Bernhard Brüne
Institute of Biochemistry I
Faculty of Medicine
Goethe-University Frankfurt
Theodor Stern Kai 7
60590 Frankfurt am Main