A06 - Role of the cytochrome P450-soluble epoxide pathway in the regulation of lymphangiogenesis

This project will address the hypothesis that activation of the cytochrome P450/soluble epoxide hydrolase (sEH) pathway affects lymphangiogenesis under physiological and pathophysiological conditions. A series of in vitro and in vivo models will be used to identify epoxide- and diol–dependent alterations in signalling and metabolism that contribute to lymphatic endothelial cell specification, lymphatic integrity, and lymphangiogenesis. The translational potential of interfering with this pathway to prevent the loss of lymphatic integrity after injury will also be determined.

Links:

• Institute for Vascular Signalling